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NGS °ü·Ã
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PGT-A
> Embgenix¢â PGT-A Kit (RUO)
Embgenix¢â PGT-A Kit (RUO)
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Clontech
634760
Embgenix¢â PGT-A Kit (RUO)
96 ȸ
(Package)
9,754,400¿ø
12,193,000¿ø
11.01 ~ 12.27
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Product index
PGT-A
Embgenix¢â PGT-A Kit (..
SMARTer RNA-Seq °³¿ä
[±â¼ú°³¿ä] SMARTer Tec..
RNA-Seq ¼±Åð¡À̵å
NGS ¼±Åð¡À̵å (NGS ±â..
RNA-Seq Á¦Ç°¸íÀÌ ÀÌ·¸..
mRNA-Seq (Single cell)
[New]Single cell mRNA-..
[New]Ultra low input m..
[New]High throughput, ..
Ultra low input mRNA-S..
High throughput, Autom..
Ultra low input 3¡¯end..
Stranded RNA-seq
[New](+UMI) Pico i..
[New]Pico input strand..
[New]Single cell stran..
[New]Mid Input Strande..
[New]High Input Strand..
Total RNA-Seq Kit (FFP..
ÀÓ»ó»ùÇÃ ÃÖÀû Pico Inp..
ÀÓ»ó»ùÇÃ ÃÖÀû Pico Inp..
Single cell Stranded R..
Mid Input Stranded RNA..
High Input Stranded RN..
Small RNA-Seq
Small RNA-Seq Kit
Immune-Seq
[¼±Åð¡À̵å] Immune-se..
[New]UMI Àû¿ë Human TC..
[New]UMI Àû¿ë Human BC..
[New]UMI Àû¿ë Mouse TC..
[New]UMI Àû¿ë Mouse BC..
UMI Àû¿ë Human TCR pro..
Human BCR IgG IgM H/K/..
Mouse TCR a/b Profilin..
Mouse BCR IgG H/K/L Pr..
±âŸ RNA-Seq
Full length cDNA ÇÕ¼º
Target RNA Capture for..
DNA-seq °³¿ä
[±â¼ú°³¿ä] ThruPLEX & ..
DNA-Seq ¼±Åð¡À̵å
ChIP-Seq / Meth-Seq
50pg ChIP DNA-seq Kit
DNA SMART ChIP-Seq Kit
Meth-Seq DNA Enrichmen..
Micrococcal Nuclease
Low Input DNA-Seq
ThruPLEX¢ç DNA-seq Kit
ThruPLEX¢ç Plasma-seq ..
PicoPLEX¢ç Single Cell..
High input DNA-seq
ThruPLEX¢ç DNA-Seq HV
ThruPLEX¢ç Tag-Seq HV
Single cell DNA-Seq
PicoPLEX¢ç Single Cell..
Whole Genome Amplification..
[±â¼ú°³¿ä] ThruPLEX & ..
PicoPLEX¢ç Single Cell..
PicoPLEX¢ç Single Cell..
Index Kit
ThruPLEX, PicoPLEX¿ë I..
Stranded-SMART kit¿ë U..
SMART-PLUS kit¿ë UDI (..
Unique Dual Index Kits
NGS Library Á¤·®
Library Quantification..
NGS Sample preparation
rRNA Á¦°Å½Ã¾à RiboGone..
Magnetic Separator-PCR..
DNA Fragmentation Kit
NGS ºÐ¼®¿ë PCR È¿¼Ò
SeqAmp¢â DNA Polymeras..
PrimeSTAR¢ç GXL DNA Po..
PreAmp Master Mix
NGS °ü·Ã Àåºñ
ICELL8 cx Technical No..
ICELL8¢ç cx Single-Cel..
ICELL8 cx 3 Differenti..
ICELL8¢ç cx Single-Cel..
ICELL8 cx Human TCR Pr..
ICELL8¢ç cx blank chip
Apollo¢â Library Prep ..
Apollo¢â Library Prep ..
[Legacy] NGS Products
(Legacy) PicoPLEX¢ç WG..
PGT-A ºÐ¼®À» À§ÇÑ whole genome amplification(WGA), library Á¦ÀÛ ¹× aneuploidy analysis°¡ °¡´ÉÇÑ complete workflow Á¦°ø
Trophoectoderm embryo (TE) biopsy sampleÀ» ÀÌ¿ëÇÑ PGT-A ºÐ¼® °¡´É
Hands-on-timeÀÌ ÀûÀº single-step WGA ¹× enzymatic fragmentationÀ» ÀÌ¿ëÇÑ NGS library Á¦ÀÛ ½Ã½ºÅÛ Á¦°ø
CNV °ËÃâÀ» À§ÇÑ Å¹¿ùÇÑ °¨µµ ¹× ÀçÇö¼º ½ÇÇö
Multiplex (24-96 »ùÇÃ) °¡´É
Miseq®, NextSeq® 500/550 Illumina sequencers Àû¿ë°¡´É – º°µµ ÇÁ·ÎÅäÄÝ Á¦°ø
Unique dual index(UDI)¸¦ Àû¿ëÇÑ multiplex ºÐ¼® °¡´É
Á¦Ç°¼³¸í
Embgenix™ preimplantation genetic testing for aneuploidy (PGT-A, À̽ÄÀü À̼ö¼º À¯ÀüÀÚ °Ë»ç)´Â ü¿Ü ¼öÁ¤(IVF)½Ã Á¤»óÀûÀÎ ¿°»öü ¼ö¸¦ °¡Áø ¹è¾Æ¸¦ ½Äº°ÇÏ¿© ¼º°øÀûÀÎ ÀӽŠ°¡´É¼ºÀ» ÃÖ´ëÈÇÏ´Â ¿¬±¸¿¡ È°¿ëÇÒ ¼ö ÀÖµµ·Ï ¼³°èµÈ ¿¬±¸¿ë(RUO) Á¦Ç°ÀÌ´Ù. º» Á¦Ç°Àº ±¤¹üÀ§ÇÑ ºÐ¼® ¹× ÀÓ»ó °ËÁõ ¿¬±¸¿¡ µû¶ó °³¹ßµÇ¾úÀ¸¸ç ¿°»öü 21¹øÀÇ »ï¿°»öü¼ºÀ» Æ÷ÇÔÇÏ¿© 24°³ ¿°»öü Àüü¿¡¼ Àüü ¿°»öü À̼ö¼ºÀ» Á¤È®ÇÏ°Ô ½Äº°ÇÒ ¼ö ÀÖ´Ù. ¶ÇÇÑ ºÐÀý À̼ö¼º(segmental aneuploidy)°ú ¸ðÀÚÀÌÁò(mosaicism)À» ½Äº°µµ °¡´ÉÇÏ´Ù. ¸ðµç Illumina platform¿¡ Àû¿ëÇÒ ¼ö ÀÖ¾î, 󸮷®¿¡ »ó°ü¾øÀÌ PGT-A Å×½ºÆ®¸¦ Á¦°øÇÏ´Â À¯ÀüÀÚ °Ë»ç½Ç ¹× IVF Ŭ¸®´Ð¿¡¼ »ç¿ëÇÒ ¼ö ÀÖ´Ù.
º» Á¦Ç°Àº WGAÀÇ gold-standard·Î ¾Ë·ÁÁ® ÀÖ´Â PicoPLEX ±â¼ú°ú NGS ºÐ¼®¿ë library »ý¼ºÀ» °£¼ÒÈÇϱâ À§ÇÏ¿© UDI¸¦ ÀÌ¿ëÇϴ ƯÇã ¹ÞÀº library Á¦ÀÛ ±â¼úÀ» Àû¿ëÇÏ¿´´Ù. PicoPLEX ±â¼úÀÇ quasi-random priming technology´Â ´ÜÀÏ ¼¼Æ÷¿Í ¼Ò·®ÀÇ DNA¿¡¼ À̼ö¼º(aneuploidy)¹× º¹Á¦¼ö º¯ÀÌü(copy number variants, CNV) ºÐ¼®ÀÌ °¡´ÉÇϵµ·Ï Çϸç, Á¤È®ÇÏ°í ÀçÇö °¡´ÉÇÑ °ËÃâ °á°ú¸¦ Á¦°øÇÑ´Ù. °£ÆíÇÑ ÇÁ·ÎÅäÄÝÀº ºÐ¼®¿¡ °É¸®´Â ½Ã°£À» Å©°Ô ´ÜÃà½ÃÄ×°í, handling errors¿Í background¸¦ °¨¼Ò½ÃÄ×´Ù. Library Á¦ÀÛ °úÁ¤(fragmentation, repair, ligation, amplification, indexing)Àº ´ÜÀÏ Æ©ºê¿¡¼ 2½Ã°£ À̳»¿¡ ¿Ï·áÇÒ ¼ö ÀÖÀ¸¸ç, Áß°£ Á¤Á¦³ª »ùÇà À̵¿ÀÌ ºÒÇÊ¿äÇÏ¿© »ùÇÃÀÇ È¥ÀÔÀ̳ª ¼Õ½ÇÀ» ÃÖ¼ÒȽÃų ¼ö ÀÖ´Ù.
´ç»ç´Â ¶ÇÇÑ NGS ÈÄ µ¥ÀÌÅÍ ºÐ¼® ¹× º¸°í¸¦ À§ÇØ »ç¿ëÇÒ ¼ö Àִ Ŭ¶ó¿ìµå ±â¹ÝÀÇ »ý¹°Á¤º¸ÇÐ ÆÄÀÌÇÁ¶óÀÎÀÎ Embgenix™ ºÐ¼® ¼ÒÇÁÆ®¿þ¾î(RUO)¸¦ Á¦°øÇÑ´Ù. ÀÌ ¾Ë°í¸®ÁòÀº ¿°»öü CNVÀÇ Á¤È®ÇÑ È®ÀÎÀ» À§ÇØ ³»ºÎÀûÀ¸·Î °è»êµÈ ÂüÁ¶¸¦ ±âÁØÀ¸·Î bin count¸¦ »ç¿ëÇÏ¿© compute calculated copy number (CCNs, °è»êµÈ »çº»¼ö)¸¦ °è»êÇϵµ·Ï µÇ¾î ÀÖ´Ù. ÀÌ ¼ÒÇÁÆ®¿þ¾î´Â Àüü ¿°»öü (whole chromosome), ºÐÀý(segmental) ¹× ¸ðÀÚÀÌÅ©(mosaic) À̼ö¼º¿¡ ´ëÇØ ÀÚµ¿ ¹×/¶Ç´Â ¼öµ¿À» ¼±ÅÃÇÏ¿© ºÐ¼®ÇÒ ¼ö ÀÖÀ¸¸ç, µ¥ÀÌÅÍ´Â Â÷Æ® ¶Ç´Â À̵ð¿À±×·¥ Ç÷Կ¡¼ Æí¸®ÇÏ°Ô ½Ã°¢È ÇÒ ¼ö ÀÖ´Ù. ÀÌ ¼ÒÇÁÆ®¿þ¾î´Â ÇÊ¿ä¿¡ µû¶ó ÆíÁýµÈ PDF º¸°í¼(´Ù¿î·Îµå °¡´É)µµ Áö¿øÇÑ´Ù.
Embgenix™ Analysis Software ´Ù¿î·Îµå
±×¸²1. Embgenix PGT-A Kit (RUO)¸¦ ÀÌ¿ëÇÑ NGS ºÐ¼® ÇÁ·Î¼¼½º
±×¸²2. ¿°»öü 18¹ø¿¡ »ï¿°»öü(trisomy)¸¦ °¡Áö°í ÀÖ´Â genomic DNA¸¦ ºÐ¼®ÇÑ Embgenix™ plot °á°ú
Embgenix¢â PGT-A¸¦ ÀÌ¿ëÇÏ¿© gDNA »ùÇÿ¡¼ ¿¡µå¿öÁî ÁõÈıº°ú ¿¬°üµÈ ¿°»öü 18¹ø(Chr18)ÀÇ ¿°»öü À̼ö¼ºÀ» Á¤È®ÇÏ°Ô ¿¹ÃøÇÏ¿´´Ù.
±×¸²3. Embgenix™ PGT-A KitÀ» ÀÌ¿ëÇÑ ºÐÀý À̼ö¼º(segmental aneuploidy) °ËÃâ
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ÅÍ³Ê ÁõÈıº(Turner Syndrome)°ú ¿¬°üµÈ ChrXÀÇ µÎ °³ÀÇ ºÐÀý À̼ö¼ºÀ» È®ÀÎÇÏ¿´À¸¸ç,
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³ú¼öÁ¾(hydrocephalus)°ú ¿¬°üµÈ Chr8ÀÇ µÎ °³ÀÇ ºÐÀý À̼ö¼ºÀ» Á¤È®ÇÏ°Ô ¿¹ÃøÇÏ¿´´Ù. µÎ ½ÇÇè ¸ðµÎ Coriell gDNA »ùÇÃ, NA13019¸¦ ÀÌ¿ëÇÏ¿´´Ù
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Embgenix PGT-A Core Kit (RUO) (Cat. No. 634761) (Not sold separately)
Unique Dual Index Kit (1–96) (Cat. No. 634752)
NucleoMag™ NGS Clean-up and Size Select (Cat. No. 744970.5)
»ó¼¼ÇÑ ±¸¼ºÇ°°ú º¸Á¸ ¿Âµµ´Â »ç¿ëÀڸŴº¾ó¿¡¼ È®ÀÎÇØ ÁÖ¼¼¿ä.
Keyword :
PGT-A
Embgenix¢â PGT-A Kit (RUO)